What is the purpose of a levigating agent?


LEVIGATING AGENTS The liquid, called a levigating agent, is somewhat viscous and has a low surface tension to improve ease of wetting the solid. Levigating agents act as lubricating agents. They make incorporating solids easier, and they usually give smoother preparations.

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Herein, how much are levigating agents?


Term Semisolid Definition Definition Attribute of a material characterized by a reduced ability to flow or conform to its container at room temperature.
Term How much levigating agent to use? Definition 4-6% w/w ; use specific gravity

Additionally, what is the difference between trituration and Levigation? Trituration is the continuous rubbing or grinding of the powder in a mortar with a pestle. Levigation reduces the particle size by triturating it in a mortar or spatulating it on an ointment slab or pad with a small amount of a liquid in which the solid is not soluble.

Secondly, what is Levigation method?

Levigation is the process of grinding an insoluble substance to a fine powder, while wet. The material is introduced into the mill together with water, in which the powdered substance remains suspended, and flows from the mill as a turbid liquid or thin paste, according to the amount of water employed.

What is an absorption base?

An absorption base is an oleaginous base that contains a w/o emulsifying agent. When water is taken up into the base, it will form a w/o emulsion. Absorption bases typically can incorporate about 50% of their volume in water.

What is a hydrophilic base?

Hydrophilic Ointment Base is a traditional oil-in-water emulsion containing petrolatum and propylene glycol. It is easy to spread and water-washable. Hydrophilic Ointment Base can accept some water to create a thinner base for compounding topical lotion preparations.

What is the base of ointment?

Petrolatum (which may be stiffened with wax) is the most widely used greasy ointment base and is suitable for the incorporation of oleaginous materials. Ointment bases are usually pharmacologically inert but may entrap water and serve to keep the skin from dying or to provide an emollient protective film.

What is sterile and non sterile?

NonSterile Compounding. Nonsterile compounding involves creating a medication in a clean environment but does not require the environment to be completely free from all microorganisms.

What is complex non sterile compounding?

Complex nonsterile compounding: compounding of drug preparations which require special training, a special environment or special facilities or equipment or the use of compounding techniques and procedures that may present an elevated risk to the compounder or the patient. ( MGL 112 section 39D)

What type of ointment base is aquaphor?

In accordance with the Food and Drug Administration’s OTC Skin Protectant Monograph Aquaphor, containing 41 percent petrolatum (active ingredient), temporarily protects minor cuts, scrapes, and burns; protects and helps relieve chapped or cracked skin and lips; helps protect from the drying effects of wind and cold

What is geometric dilution?

Geometric dilution is a pharmaceutical process that thoroughly mixes a small amount of a. drug with an appropriate amount of a diluent, an inert substance that thins or binds the drug. It. ensures equal distribution of the drug throughout the resulting compound, according to the UNC.

What is pulverization by intervention?

Pulverization by intervention is the process of reducing the size of particles in solid using the aid of an additional material in which that material is soluble – a volatile solvent that evaporates. What is “Spatulation”? Spatulation is the process of combined substances by means of a spatula.

What is the correct technique of Triturating substances?

Trituration Method. A trituration is a dilution of a potent drug powder with an inert diluent powder, usually lactose, in a definite proportion by weight. We can then remove a weighable portion (aliquot) of the mixture containing the desired quantity of substance to maintain an acceptable range of accuracy.

What is geometric mixing?

Geometric dilution is a pharmaceutical process that thoroughly mixes a small amount of a drug with an appropriate amount of a diluent, an inert substance that thins or binds the drug. It ensures equal distribution of the drug throughout the resulting compound, according to the UNC Eshelman School of Pharmacy.

What is a compounding log?

Designed for recording entries of compounded prescriptions. The log will assist staff in identifying the specific ingredients used, supplier, expiration date, lot numbers and the quantity measured or weighed.

What is comminution in pharmacy?

Comminution. Comminution is the process of physical reduction of a substance to fine particle size, which makes the substance or drug easier to dissolve and compound. The processes for comminution are cutting, grating, grinding, pulverizing, trituration, and levitation.

What is the purpose of trituration?

In one sense, it is a form of comminution (reducing the particle size of a substance). For example, a dental amalgam is formed by combining particles of a metal, usually gold or silver, with mercury. In organic chemistry, trituration is a process used to purify crude chemical compounds containing soluble impurities.

What are simple and compound powders?

Simple & Compound Powders for Internal Use ? In this form of powder, each individual dose is enclosed in paper. ? The number of ingredient is one i.e. simple powder while more than one i.e. compound powder.

What is moderately coarse powder?

Moderately coarse powder

A powder all the particles of which pass through a sieve with a nominal mesh aperture of 710 ~ and not more than 40 percent by weight through a sieve with a nominal mesh aperture of 250 ~.

What is flow property?

Abstract. The flow properties of powders and bulk solids depend on several parameters, e.g., particle size distribution, moisture, temperature. Often flow properties vary with stress level. Flow agents, added to a bulk solid, can improve flow behavior.

What are the properties of powder?

Food powders are a diverse group of particulates. They vary considerably with respect to composition, microstructure, particle size and the physical properties that stem from them. Among these are cohesion, flowability, density, compressibility, mechanical strength, and segregation tendency.

What is compound powder?

Compounding Powders. In compounding, “powder” refers to a dosage form that exists as fine particles. The formulation may contain only the active drug or may be mixed with other ingredients.